在微波无溶剂无催化条件下,以取代吡唑甲醛、芳胺和亚磷酸二乙酯为原料合成了一系列新型含吡唑基的α-氨基膦酸酯类衍生物,其结构经^1H NMR,^13C NMR,MS和^31P NMR测试技术进行了表征.初步生测结果表明,部分化合物表现出不同程度的抗菌活性.
A series of novel a-aminophosphonate derivatives containing substituted pyrazole were synthesized with substituted pyrazolyl aldehyde, arylamine and diethylphosphone under microwave-assisted without using any catalysts and solvent. And the structures of the compounds were confirmed by ^1H NMR, ^13C NMR, ^31p NMR and MS techniques. Preliminary bioassay indicated that some of them showed good fungicidal activities.