中文摘要：

地球表面的生物体会受到来自阳光紫外辐射的照射。两极臭氧层空洞的形成使地球表面的紫外辐射水平,特别是UVB的水平增加,进而对生物体的危害日益加重。因此,深入研究紫外辐射生物学效应的信号转导机制并阐明其损伤机制和生物体的反应机制等具有重要意义,也可为紫外辐射损伤防护的研究提供新思路。本文综述了本领域近年来的相关研究,从紫外辐射所致生物学效应的信号转导机制（包括对DNA的直接损伤作用、细胞膜激酶和非激酶受体通路、细胞质通路以及microRNA）等方面对紫外辐射的损伤机制进行了比较系统的阐述和总结。

英文摘要：

Organisms living on the Earth are more or less exposed to sunlight ultraviolet （UV） radiation. Ozone hole above both poles that has made the earth＇s surface UV radiation level, especially that of UVB, increased and then the damage to organisms become heavier and heavier. Therefore, it is important to clarify UV radiation damage mechanisms and organisms reaction mechanisms to ultraviolet radiation. In this paper, signal transduction mechanisms involved in UV radiation-induced biological effects, including direct damage on DNA, cell membrane receptor kinases and non-kinase signal pathways, cytoplasmic pathway, and microRNA were systematicly exposited and summaried.