中文摘要：

IKK（inhibitor of NF-κBkinase）复合体的催化亚基IKKα,调节NF-κB激活。在表皮组织中,IKKα已被证明是一个调节角质细胞增殖、分化和致癌性转化的关键调节子,它在阻止皮肤角质层角质细胞和真皮层成纤维细胞转化为恶性肿瘤方面扮演了重要角色,这一发现为预防皮肤癌提供了新的治疗标靶。本文总结了IKKα在表皮分化和皮肤癌中有关的信号通路,以及它们所形成的一个以IKKα为中心的信号网络,这为研究皮肤分化及皮肤癌的发病机理提供了理论基础和新视角。

英文摘要：

The alpha subunit of IKK （inhibitor of NF-κB kinase） complex,IKKα,is one of the two catalytic subunits of the IKK complex involved in NF-κB activation.In epidermis tissues,IKKα is the main regulator that modulates proliferation,differen- tiation and transformation of keratinocytes and plays an important role in preventing keratinocytes in upper epidermis and fibroblasts in the lower dermis from malignant tumor.The findings propose a new target for the prevention of skin cancer treatment.This paper summarizes the IKKα signaling pathways in epidermal differentiation and skin cancer and the IKKα- centered signal network based on these pathways,which provides a theoretical foundation and a new perspective for skin differentiation and the pathogenesis of skin cancer.