中文摘要：

目的：探讨帕罗西汀预防创伤后应激障碍（PTSD）的效果。方法：矿难2个月后对31名矿难幸存者和22名配偶非PTSD者随机分为预防组和对照组。预防组予帕罗西汀10mg／d或20mgZd进行干预。1个月后再次进行PTSD诊断，干预前后对两组进行PTSD自评量表和PTSD症状清单（PCL）评定。结果：1个月后对照组有4人符合PTSD诊断标准，预防组无1例PTSD者。干预前，预防组和对照组PTSD自评量表及PCL评分差异无显著性（P＞0．05）。干预后，预防组PTSD总分、PTSD闪回因子以及PCL评分比干预前显著减少（P＜0．05或P＜0．01），对照组仅PCL评分比干预前显著下降（P＜0．05）。干预后预防组与对照组闪回及PTSD总分差异显著（P＜0．05或P＜0．01）。结论：帕罗西汀对PTSD的发生有预防作用。

英文摘要：

Objective： To explore the efficacy of paroxetine in prevention from posttraumatic stress disorder （FI＇SD）. Method ：31 survivors in a mine disaster and 22 survivor spouses were randomly divided into prevention group and control group two months affter the disaster, the prevention group was treated with paroxetine of 10 or 20 mg/d for one month. PTSD checklist （PCL） and PTSD self rating scale were administered before and after the treatment. Results：After one month treatment, there were no peoples in prevention group but 4 persons in control group who met the prI＇SD criteria of DSM-IV. The two groups showed no significant differences on scores of PTSD self rating scale and PCL scale before the treatment （ P〉0.05 ）. Prevention group revealed significant decrease in total as well as flashback score of PTSD self rating scale and PCL score after the treatment （ P 〈 0. 05 or P 〈 0.01 ） , while control group significantly decreased only in PCL score （ P 〈 0.05 ）. There were significant differences on total as well as flashback score of PTSD self rating Scale after the treatment between the two groups. Condusion：Paroxetine can be applied to prevention from PTSD.