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中文摘要：
目的 研究重离子和X射线全身照射小鼠对骨髓细胞周期分布的影响，为面向生物学对象的重离子治疗提供基础数据。方法用X射线和重离子照射BALB／c小鼠后，24h后制得骨髓细胞，采用PI染色用流式细胞仪测骨髓细胞周期变化。结果照射24h后，X射线照射的各组骨髓细胞周期分布与对照组差异没有统计学意义；重离子照射组与对照组相比，出现G1／G0期和G1／M期阻滞，与相同剂量X射线照射组相比亦出现G1／G0期和G2／M期阻滞。结论 相同剂量的重离子照射较X射线对骨髓细胞的损伤更严重，引发不同的生物学效应。
英文摘要：
Objective To investigate the effects of whole body irradiation with heavy ions and X-ray at different doses on mice bone marrow cell cycle distribution, and to provide the basic data for biological-objectoriented hadrontherapy（OOBH）. Methods The BALB/c mice were irradiated with heavy ions and X-ray, and the bone marrow cells were harvested after 24 hours, and then the cell cycle distribution were analyzed by flow cytometry. Results At 24 h after irradiation, bone marrow cell cycle distribution of the X-ray groups were not different from the control. While in the heavy ions irradiation groups, G1/G0 phase and G2/M phase were markedly arrested compared with the control group as well as X-ray irradiation group at the same dose. Conclusions The heavy ions irradiation was more dangerous on the mice bone marrow cells than the X-ray irradiation at the same doses. They induced different relative biological effects.
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