中文摘要：

Erythropoietin (EPO ) 是传播 glycosylated 蛋白质荷尔蒙并且在非造血的织物肿瘤的发展和前进被含有。现在的学习的目的是决定 EPO rs576236 多型性是否与肾的肿瘤的风险被联系。我们 genotyped 在由使用 TaqMan 方法的 288 个肾的肿瘤病人和 456 没有癌症的控制的盒子控制研究的 EPO rs576236 多型性，并且由逻辑回归估计了在多型性和肾的肿瘤风险之间的协会。而且， 95% 信心间隔(CI ) 被用来估计在多型性和肾的肿瘤的风险之间的基因协会。与 TT 遗传型相比， TC 遗传型有肾的肿瘤的显著地增加的风险[调整机会比率(或) ； = ；1.24， 95% CI  ； = ；1.12-2.22 ] 。而且，肾的肿瘤的显著地增加的风险与 TT 遗传型相比在联合变体遗传型 TC+CC 被发现(调整或  ； = ；1.17， 95% CI  ； = ；1.12-2.21 ) 。我们的现在的学习建议 EPO 的 rs576236 多型性在中国人口授与危险性到肾的肿瘤。

英文摘要：

Erythropoietin（EPO） is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval（CI） was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio（OR） = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC＋CC compared with the TT genotype（adjusted OR = 1.17,95%CI = 1.12-2.21）.Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.