中文摘要：

目的分析伴有t（7；11）（p15；p15）的急性髓系白血病（AML）患者的临床和实验室特征。方法对11例伴有t（7；11）（p15；p15）的AML患者进行回顾性分析，包括细胞形态学、细胞免疫表型、细胞遗传学和临床预后。结果11例患者中8例为女性，AML—M2a6例，M4、M5各2例，M61例。11例患者均表达CD33，其中10例表达CD117、CD13，7例表达HLA—DR，6例表达CD34。11例患者染色体核型均显示有t（7；11）（p15；p15），其中1例伴有＋8。共9例患者检测FLT3-ITD、TKD突变，其中1例FLT3-ITD突变阳性。11例患者仅2例存活，1例失访；其余8例均死亡。结论t（7；11）（p15；p15）异常是一种少见的染色体易位，伴有该异常的AML患者具有贫血、血小板减少、白细胞升高的临床特征，预后不良。

英文摘要：

Objective To investigate clinical and laboratory characteristics of acute myeloid leukemia （AML） patients with t（7;11） （p15 ;p15）. Methods Eleven patients with t（7;ll） （p15;p15） were retrospectively reviewed involved in cell morphology, immunophenotype, eytogeneties as well as clinical features and prognosis. Results Eight patients out of the eleven were female, six patients were AML-M2a, two M4, two M5 , and one M6. All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively. Karyotypes of all the patients were t（7 ; 11 ） （ p15 ;p15）, additional trisomy 8 were found in only one patient. FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD. Two patients were alive, and one lost to followed up, while the rest of eight were dead. Conclusion The t（7;11 ） （p15;p15） abnormalities is one of rare chromosomal transloeation in patients with AML. AML patients with t（7;11 ）（p15;p15） have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.