中文摘要：

选用了10种典型的P，N-双齿配体并合成相应的Au（I）配合物；以8-甲基喹啉-氮氧化物为氧化剂，Au（I）配合物／金属盐为催化剂，在氧化端炔与硫代酰胺反应制备2，4-二取代噻唑的反应中，考察了不同的金属盐对催化剂性能的影响，优化了反应参数；结果表明，5m01％Mor—DalPhosAuCl／10mol％Zn（NTf2）2催化体系在该反应中显示出了较高的催化活性，且“一步法”高效地合成了10种2,4-二取代噻唑化合物，为噻唑及其衍生物的制备探索出了一条简便直接的合成路线．

英文摘要：

Ten typical P,N-bidentate ligands were selected to synthesize the corresponding Au（I） complexes. The catalytic system of Au（I） complex/metal salt was employed in the catalytic oxidation of terminal alkynes with the oxidant of 8-methylquinoline N-oxide. And then 2,4-disubstituted thiazoles were synthesized from the oxidized alkynes and thioamides. It was found that the catalytic system of 5 tool% Mor-DalPhosAuC1/10 mol% Zn（NTf2）2 showed the optimum catalytic perfor- mance in this reaction via adjusting reaction parameters. Furthermore, ten kinds of 2,4-disubstituted thiazoles were effectively synthesized in one-step. So a simple and direct synthetic route was explored for the preparation of thiazoles and their deriva- tives.