目的观察化瘀通络灸法治疗血管性痴呆(VaD)在改善临床症状及量化表积分和调控血管活性物质方面的作用。方法将86例VaD患者按随机数字表法分为艾灸治疗组与西药治疗组,经2个疗程治疗后,比较两组治疗后智能检查量表(HDS)积分、智能改变量表(MMSE)及日常生活能力量表(ADL)积分变化,以及与学习记忆相关的血管活性物质血浆一氧化氮(NO)、内皮素(ET)水平。结果艾灸治疗组疗效优于西药治疗组;两组治疗前后HDS、MMSE与ADL量表积分比较均有显著性差异,艾灸治疗组MMSE量表积分改善优于西药治疗组;艾灸治疗后血浆NO水平明显升高,ET水平显著下降,与西药治疗组比较均有显著性差异。结论化瘀通络灸法在改善临床相关症状积分及调控血管活性物质方面均具有独特的优势。
Objective: To observe the effect of Huayutongluo Moxibustion in improving clinical symptoms, the quantifying points table and the regulation of vasoactive material of vascular dementia(VaD) . Methods: 86 cases of VaD patients were randomly divided into the group of moxibustion and the western medicine. After 2 period of treatment, the examination integration(HDS), intelligent scale change(MMSE), and scale of daily living(ADL) score changes were recorded before and after treatment, and the learning and memory- related vasoactive substances in plasma nitric oxide(NO), endothelin(ET)levels were also recorded. Results: The moxibustion group was more effective than western medicine group. The two groups HDS, MMSE and ADL scale score were significantly different after treatment. The moxibustion group MMSE scale score was better than improvement of western medicine group. The plasma level of NO was increased, and ET was decreased significantly in moxibustion group, also had obvious difference compared with western medicine group. Conclusion: Huayutongluo Moxibustion in improving the clinical symptoms and regulating vasoactive substances have distinctive advantages.