中文摘要：

目的：通过结直肠癌体外药物敏感性实验,分析临床病理因素与7种化疗药物体外药敏结果相关性,从而为临床选择化疗药物提供理论依据。方法：收集100例新鲜人结直肠癌标本,均经病理证实为癌。采用三维微组织块培养法（HDRA）比较7种化疗药物的体外敏感性。成功完成83例,同时评价体外药敏结果与临床病理参数之间的相关性。结果：7种化疗药物的体外敏感性结果依次为：5-FU 43.93%、奥沙利铂52.00%、伊立替康25.39%、培美曲塞33.13%、雷替曲塞32.01%、多西紫杉醇16.73%、吉西他滨23.14%。体外药敏结果与患者年龄、性别、部位、淋巴结转移、分期没有明显相关性,而与分化程度呈负相关。结论：体外药敏实验对临床用药具有一定指导意义,结直肠癌分化水平与化疗药物体外药敏结果具有一定相关性。

英文摘要：

Objective： To investigate the chemosensitivity of freshly- removed colorectal tumor specimens. Methods： We collected 83 freshly- removed colorectal tumor specimens,chemosensitivities to seven chemotherapy drugs were detected by HDRA,and to explore the relationship between clinilcopathological features and chemosensitivities.Results： The inhibitions of seven drugs were as follows： 5- FU 43. 93%,Oxaliplatin 52. 00%,Irinotecan 25. 39%,Pemetrexed 33. 13%,Raltitrexed 32. 01%,Docetaxel 16. 73%,Gemcitabine 23. 14%. There were no significant associations between age,gender,site,lymphonode metastasis,stage and chemosensitivity. However,there was significant relationship between grade and chemosensitivity. Conclusion： Chemotherapy under the guidance of in vitro chemosensitivity may be a good choice in colorectal cancer. Grade can be a predictor in chemosensitivity in colorectal cancer.