中文摘要：

Bmi-1，一个 polycomb 基因家庭成员，在房间周期规定，房间不减，和房间老朽起一个重要作用。最近，众多的研究证明了 Bmi-1 涉及自强的规定和干细胞的区别。然而，位于这个生物过程下面的分子的机制仍然保持大部分不清楚。在现在的评论，我们作为基因表示的一个 transcriptional 管理者总结了 Bmi-1 的函数，与干细胞的特别参考。

英文摘要：

Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized the function of Bmi-1 as a transcriptional regulator of gene expression, with particular reference to stem cells.