中文摘要：

目的探讨本地区非综合征型单纯腭裂的危险因素，为早期预防提供依据。方法采用病例对照研究方法，对江苏及周边地区非综合征型单纯腭裂患儿进行了环境影响因素的流行病学调查，采用单因素及多因素条件Logistic回归分析筛选出与非综合征型单纯腭裂易感性有关的因素，使用SPSS19．0进行统计分析。结果共计63例非综合征型单纯腭裂患者以及209例健康对照纳入本研究。多因素分析发现家族遗传史（OR=19．808）、胎次（OR=3．876）、孕期被动吸烟（OR=5．076）、孕期母亲饮酒（OR=9．414）、孕期感染（OR=12．346）和父亲文化程度低（OR=2．780）是非综合征型单纯腭裂发生的危险因素。结论家族遗传史、胎次、孕期被动吸烟、孕期母亲饮酒、孕期感染和父亲文化程度低可能是江苏省及其周边地区非综合征型单纯腭裂的危险因素。

英文摘要：

Objective To explore the risk factors of non-syndromic cleft palate, which is helpful for its early prevention. Methods A case-control study was performed to detect the environmental risk exposure of non-syndromic cleft palate cases. Univariate and multi- ple conditional Logistic regression analysis were used to explore the association between risk factors and the risk of non-syndromic cleft palate. And SPSS 19.0 was applied to do the statistical analysis. Results In total, 63 non-syndromic cleft palate cases and 209 healthy controls were recruited in this study. The results of multivariate analysis indicated that family history （ OR= 19.808）, pregnancy parity （ OR = 3.876） , passive smoking during pregnancy （ OR = 5.076） , alcohol drinking during pregnancy （ OR = 9.414） , infection during pregnancy （OR= 12.346） and low education level of father （OR= 2.780） were risk factors of non-syndromic cleft palate. Conclusions Family history, pregnancy parity, passive smoking during pregnancy, alcohol drinking during pregnancy, infection during pregnancy and low education level of father may be the main risk factors influencing the occurrence of non-syndromic cleft palate in Jiangsu and its surrounding areas.