中文摘要：

目的酪氨酸激酶B（TrkB）在前列腺癌、前列腺增生中的表达和临床病理特征及其与生物学行为的关系。方珐前列腺肿瘤标本60例，其中前列腺增生标本14例，前列腺癌标本46例，均为存档石蜡切片，应用免疫组织化学（SP法）研究TrkB表达。结果TrkB在前列腺增生组织表达为14．29％，在前列腺癌组织为80．43％，两者之间差异有统计学意义（X^2=12．26，P〈0．01）。TrkB表达水平在与Gleason评分之间呈正相关（r=0．672，P〈0．001），在不同临床TNM分期组间，在血清PSA浓度≤20ng／mL与〉20ng／mL组间差异无统计学意义（P〉0．05）。结论TrkB很可能是前列腺发病过程中起重要作用的分子，并有可能作为判断前列腺癌患者诊断和治疗的靶基因。

英文摘要：

Objective To study the expression of tyrosine kinase B （TrkB） and to investigate its clinical and pathological implications in prostate cancer. Methods Formalin-fixed, paraffin-embedded tissue sections from 46 cases of prostatic carcinoma （PCA） and 14 cases of benign prostate hyperplasia （BPH） were analyzed retrospectively with immunohistochemistry （ S-P method）. Results The TrkB gene was highly expressed in prostatic carcinoma tissues, but not in benign ones. Positive expression of TrkB proteins was detected in 2 of the 14 （14.29%） benign tumor samples and accounted for 80.43% in prostatic carcinoma ones, and statistical significance had been conformed between the two groups （X^2 = 12. 26, P 〈 0. 01） . Furthermore, positive expression of TrkB in prostatic carcinoma samples inecreased significantly with the increasing of the gleason score（ r = 0. 672, P〈0. 001）. However, positive expression of TrkB was not correlated with tumor stages or the concentrations of prostate-specific antigen（PSA）in blood serum （P〉0. 05）. Conclusion TrkB may play an essential role in prostate carcinogenesis and serve as a marker for the prognosis of prostate cancer.