中文摘要：

SCF（Skp1-Cullin1-F-box）复合体是一类泛素E3连接酶,F-box蛋白是构成SCF复合体的亚基之一,在泛素蛋白酶体途径（ubiquitin-proteasome pathway,UPP）中介导SCF复合体特异性的识别底物。SCF复合体通过降解特定底物在多种细胞进程中发挥关键调节作用,如细胞增殖、细胞周期进程、转录和细胞凋亡等。F-box蛋白参与的蛋白降解过程的失调会导致肿瘤的发生,所以可针对F-box蛋白进行癌症药物的设计。该文主要对F-box蛋白家族的结构特征和它们在肿瘤发生中的功能进行了系统阐述,为其将来作为药物靶点应用于癌症临床治疗提供理论基础。

英文摘要：

SCF（Skp1-Cullin1-F-box） complex is a kind of E3 ubiquitin ligase. F-box proteins, one of the subunits that constitute the SCF complexes, mediate the substrate recognition specificity of SCF complex in the ubiquitin-proteasome pathway. Many cell processes, such as cell proliferation, cell-cycle progression, transcription and cell apoptosis, can be regulated by SCF complex through the degradation of specific substrates. The dysregulation of the protein degradation mediated by F-box proteins has been recognized to be closely related to tumorigenesis, so we can design the anticancer drugs targeting F-box proteins. In this review, we summarize the structure characteristics of F-box proteins and try to elucidate the role of F-box proteins in tumorigenesis. This review may provide a new theoretical basis on cilinical treatment of cancer and F-box protein-targeted drug design.