中文摘要：

肺纤维化（pulmonary fibrosis，PF）形成过程中涉及细胞外基质（extracellula matrix，ECM）大量沉积，其主要来源于肌成纤维细胞（myofibroblast，MF）。该细胞能表达α-平滑肌肌动蛋白（α—smooth muscle actin，α—SMA），是造成ECM异常沉积的主要细胞。MF的转化受多种因素调节、有多种信号途径参与，是一个错综复杂的过程。

英文摘要：

Pulmonary fibrosis is a pathologic change caused by the severe extracellular matrix accumulation,mainly originating from myofibroblast which can express α-smooth muscle actin,and it is the major induces the extracelluar maxtrix. Its complicated transforming process is regulated by multiple factors and cell that participated by multiple singal transduction pathways.