中文摘要：

目的：观察雾化吸人布地奈德对大鼠肺纤维化的干预作用并探讨其作用机制。方法：45只Wistar雌性大鼠随机分为生理盐水对照组、肺纤维化模型组、布地奈德干预组，每组15只。利用博菜霉素建立肺纤维化模型，24h后给予布地奈德干预，并分别于7、14、28天处死动物，观察其肺组织病理变化、肺系数、肺组织胶原含量及支气管肺泡灌洗液（BALF）转化生长因子-β1（TGF-β1）的表达。结果：与模型组比较，布地奈德组的肺泡炎和肺纤维化程度明显减轻，肺组织胶原含量、BALF中TGF—β1表达水平均降低（P〈0．05）。结论：雾化吸入布地奈德能够抑制致肺纤维化因素导致的肺部正常组织结构的破坏及肺组织胶原的沉积，从而有效阻止肺纤维化的进展。

英文摘要：

Objective： To observe the effect of inhaled budesonide on pulmonary fibrosis induced by bleomycin in rats and to explore its mechanism. Methods： 45 rats were randomly divided into control group（CG）, model group （MG） and budesonide intervention group （BG）. The pulmonary fibrosis model was established by a single intratraeheal instillation of bleomycin. After 24 h,both CG and MG were aerosolized with 0.9%NaCl solution, while BG was aerosolized with budesonide. On the 7th,14th and 28th after treatment,5 rats of each group were sacrificed,and their lungs were harvested to exam the lung index,pathology change, content of collagen. Bronchoalveolar lavage fluid （BALF） was collected and the concentration of TGF-β1 in BALF was detected. Results：Budesonide could obviously alleviated alveolitis and fibrosis induced by bleomycin.Compared with MG , the content of collagen in lung tissue and the concentration of TGF-β1 in BALF in BG decreased （P〈 0.05）.Conclusion： Inhaled budesonide may obviously inhibited the development of pulmonary fibrosis induced by blcomycin in rats.