中文摘要：

目的分析中国乙肝病毒（HBV）的基因型间重组情况,寻找新的重组体。方法下载GenBank中所有来自中国的人HBV全基因组序列,运用片段分型法分析筛选HBV疑似重组序列,并利用生物信息学软件Simplot鉴定重组事件及重组断点。结果1642条人全长HBV序列中发现755条重组序列,共31种重组体。其中B/C重组体22种676条重组序列;C/D重组体5种75条重组序列;A/C重组体3种3条重组序列;C/I重组体1种1条重组序列。排除已有文献报道的重组类型,总共发现4种共4条重组序列。结论在GenBank所有的来自中国地区的HBV全基因组序列中发现31种重组体,其中4种重组体为首次发现,并且C基因型参与中国地区所有的基因型间重组。

英文摘要：

Objective To identify the intergenotype recombination of hepatitis B virus （HBV） in Chinese patients and explore new recombination types of HBV. Methods Complete genome sequences of HBV from Chinese patients were downloaded from GenBank and analyzed by Fragment-typing method to screen the potential recombinants, and the breakpoints of recombination were identified by using Simplot program. Results Thirty-one recombination types including 755 recombinants were identified from 1642 complete HBV genome sequences, including 22 B/C recombination types with 676 recombinants, 5 C/ D recombination types with 75 recombinants, 3 A/C recombination types with 3 recombinants, and 1 C/I recombination type with I recombinant. Conclusion Of the 31 recombination types comprising 755 recombinants, 4 are novel recombination types found for the first time. All these recombination types identified in this study involve genotype C.