中文摘要：

microRNA是一类含有19-22个核苷酸的非编码RNA,在转录后水平调控基因的表达,参与多种生物学过程,如细胞分化、增殖、凋亡和代谢。microRNA-182（mi R-182）属于miR-183/96/182簇（cluster）的一员,在多种细胞和组织中表达,如成骨细胞、淋巴细胞、视网膜、内耳以及脂肪组织等。研究显示miR-182在这些组织器官的正常分化、发育和功能的维持等方面均发挥了重要作用,而它的异常表达则参与了包括视网膜病变、自身免疫性疾病、肿瘤、肥胖和糖尿病等多种相关疾病的发生发展。本文对miR-182在这些疾病发生发展中的作用及其可能的机制作一综述。

英文摘要：

microRNAs are a class of short non-coding RNAs containing about 19–22 nucleotides that regulate target gene expression through post-transcriptional repression or m RNA degradation,and involved in a variety of biological processes,such as cellular differentiation,proliferation,apoptosis and metabolism. micro RNA-182（miR-182）,belonging to mi R-183/96/182 cluster that consists of miR-182,-183,and-96,highly expresses in many cells and tissues,including osteoblasts,lymphocytes,adipocytes,retina,inner ear,etc. The recent studies of miR-182 highlighted its multiple important roles in differentiation,development,and functional maintenance in the cells and tissues. The dysregulation of miR-182 is associated with occurrence and development of many diseases,such as retinopathy,autoimmune diseases,cancers,obesity and diabetes. This review summarizes recent research progresses on the roles and mechanisms of miR-182 in cellular function and diseases.