中文摘要：

目的：考察透明质酸（HA）修饰的氧化石墨烯（GO）负载米托蒽醌（MIT）载药体系（MIT/HA-GO）在乳腺癌模型裸鼠体内的药动学特征和组织分布。方法：建立MIT测定的高效液相色谱法。荷瘤小鼠由尾静脉分别注射MIT、MIT/GO以及MIT/HA-GO,用上述方法检测MIT浓度,分析其在小鼠体内的药动学特征及在心、肝、肺、肾、瘤等部位的分布情况。结果：与MIT组相比,MIT/GO组及MIT/HA-GO组MIT的血循环时间均延长,且在心、肺、肾的AUC降低;MIT/GO及MIT/HA-GO在肿瘤组织的靶向效率分别为MIT的1.55和2.61倍。结论：MIT/HA-GO载药体系降低了MIT的全身毒副作用并提高了对肿瘤部位的靶向性。

英文摘要：

Aim： To investigate the pharmacokinetic characteristics and tissue distribution of hyaluronic acid（ HA）-modified mitoxantrone（ MIT）-loaded graphene oxide（ GO） in the MCF-7 tumor bearing mice. Methods： The mice were injected with MIT,MIT/GO and MIT/HA-GO via tail vein,respectively. And the pharmacokinetics study and drug distrubution in major organs of the three different formulations were determined by HPLC. Results： Compared with MIT,MIT/GO and MIT/HA-GO possessed prolonged circulation features and decreased the AUC in heart,lung and kidney. And the tumor targeting efficiency of MIT/GO and MIT/HA-GO were 1. 55 and 2. 61 times as compared with that of MIT,respectively. Conclusion：The HA-mediated MIT-loaded GO decreases the systemic toxicity of MIT and increases the tumor targeting efficiency.