中文摘要：

目的 研究帕金森病（Parkinson＇s disease,PD）患者血清犬尿氨酸（kynurenine,KYN）、犬尿喹啉酸（kynurenic acid,KYNA）和色氨酸（trptophane,TRP）浓度及代谢改变,探讨其临床意义.方法 采用高效液相色谱-荧光检测法（HPLC-FLD）检测16例首发PD患者、36例美多巴（Madopar）治疗PD患者、20例正常对照人群血清KYN、KYNA和TRP的浓度,比较血清KYN、KYNA、TRP以及KYNA/KYN和KYN/TRP比值的差异性.结果 美多巴治疗PD患者血清KYNA水平和KYNA/KYN比值较首发PD患者和正常对照人群显著升高（P〈0.01）;首发PD患者及美多巴治疗PD患者血清中TRP水平较正常对照人群显著升高（P〈0.01）.结论 采用HPLC-FLD检测PD患者血清中的KYN、KYNA及TRP的含量,可为帕金森病的临床诊断和药物治疗提供部分实验室依据.

英文摘要：

Objective To evaluate the serum kynurenine （KYN）, kynurenic acid （KYNA） and trptophane （TRP） in Parkinson＇s disease （PD） patients and healthy controls. Methods The serum KYN, KYNA and TRP levels in 16 first episode PD patients, 36 PD patients treated by Madopar and 20 age -matched healthy controls were measured by high peflormanee liquid chromatography- fluorescence （HPLC- FLD）. KYNA/KYN and KYN/TRP ratios were calculated. Results The serum KYNA level and KYNA/KYN in PD patients treated by Madopar were significantly higher than those in first episode PD patients and controls （ P 〈 0. 01 ）. The serum TRP levels in first episode or Madopar treated PD patients was significantly higher than that in controls （ P 〈 0.01 ）. Conclusion The serum KYN, KYNA and TRP levels in PD patients may be used for the diagnosis and treatment of PD.