中文摘要：

瞄准：学习在饥饿上是否加重肠的 mucosal 损害并且支持细菌并且在高高度的 hypoxic 环境的内毒素 translocation。方法：Sprague-Dawley 老鼠为 72 h 在 7000 m 的模仿的高度暴露于比重低於脑脊髓液的组织缺氧。镧硝酸盐被用作 tracer 检测肠的损害。上皮的 apoptosis 被观察，终端 deoxynucleotidyl transferase dUTP 刻痕结束标记染色。diamino oxidase (DAO ) 的浆液层次， malondialdehyde (MDA ) ，夫酸安(Gln ) ， superoxide dismutase (草皮) 和内毒素在肠的 mucosa 被测量。细菌的 translocation 在血文化和肠的 homogenates 被检测。另外，老鼠 intragastrically 被给 Gln 在肠的损害上观察它的保护的效果。结果：在肠的 Apoptotic 上皮的房间， exfoliated 绒毛和煽动性的房间在伴随红血房间的流出的薄板 propria 与浮肿被增加。镧粒子在细胞间的空间和细胞内部的分隔空间被发现。到 mesenteric 淋巴节点(MLN ) 和怒气的细菌的 translocation 是明显的。当浆液草皮， DAO 和 Gln 层次在肠是更低的时，浆液内毒素， DAO 和 MDA 层次显著地更高(P < 0.05 ) 。细菌的 translocation 数字比在高高度饥饿组在高高度 hypoxic 组是更低的(0.47 ? 潴 ?? 慥獲吗？

英文摘要：

AIM：To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic environment.METHODS：Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 h.Lanthanum nitrate was used as a tracer to detect intestinal injury.Epithelial apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling staining.Serum levels of diamino oxidase（DAO）,malondialdehyde（MDA）,glutamine（Gln）,superoxide dismutase（SOD） and endotoxin were measured in intestinal mucosa.Bacterial translocation was detected in blood culture and intestinal homogenates.In addition,rats were given Gln intragastrically to observe its protective effect on intestinal injury.RESULTS：Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood cells.Lanthanum particles were found in the intercellular space and intracellular compartment.Bacterial translocation to mesenteric lymph nodes（MLN） and spleen was evident.The serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine（P 0.05）.The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group（0.47±0.83 vs 2.38±1.45,P0.05）.The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral blood.The bacterial and endotoxin translocations were both markedly improved in rats after treatment with Gln.CONCLUSION：High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.