中文摘要：

Huperzine A（Hup-A） is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system（SMEDDS） was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion（SPIP） technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve（AUC） of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension（P <0.01）.The absorption rate constant（Ka） and the apparent permeability coefficient(Papp) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of Ka and Papp of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(Cmax) of the blocking model were significantly lower than those of the control model（P<0.05）. The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A.