中文摘要：

目的餐后高甘油三酯血症是冠心病和动脉粥样硬化的独立危险因素。本研究旨在观察一次性口服或静滴辅酶A 1000单位对空腹高甘油三酯血症患者的餐后甘油三酯水平的影响。方法经过饮食宣教后,20例患者和10例正常人进行基线高脂餐试验,采集餐前、餐后2、4、6 h的静脉血标本。20例患者分别随机分入辅酶A胶囊组和辅酶A针剂组,于第2天分别于餐前30 m in口服辅酶A胶囊1000单位或高脂餐后,立即用500 mL生理盐水注射液溶解1000单位辅酶A针剂后静脉滴注,1 h内滴完。再次采集餐前、餐后2、4、6 h的静脉血标本。检测血脂水平,并且计算餐后2、4、6 h各时间点甘油三酯水平升高的程度。结果正常人仅餐后2 h血清甘油三酯水平显著升高（P〈0.05）,患者的餐后2、4、6 h血清甘油三酯水平显著高于其空腹水平（P〈0.05）,餐后4 h达到顶峰。正常人和患者的餐后各时间点血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平与各自空腹状态相比均无显著差异。将胶囊组患者与针剂组患者合并进行统计（n=20）,结果发现：经辅酶A治疗后,餐后6 h血清甘油三酯水平升高程度显著低于基线（62.4%±13.1%比42.1%±9.2%,P〈0.05）。亚组分析显示：接受辅酶A针剂静滴的患者的餐后6 h血清甘油三酯水平和餐后6 h甘油三酯水平升高程度显著低于基线水平（P〈0.05）。口服辅酶A胶囊的患者餐后2、4、6 h血清甘油三酯水平和甘油三酯升高程度与基线状态相比无显著差异。结论小样本研究显示：餐后立即静滴辅酶A 1000单位可以显著抑制空腹高甘油三酯血症患者高脂餐后6 h血清甘油三酯水平的升高;而餐前一次性预服含保护剂的辅酶A胶囊1000单位对餐后高甘油三酯血症没有显著影响。

英文摘要：

Aim Postprandial hypertriglyceridemia is an independent risk factor for coronary heart disease and atherosclerosis.This study was designed to explore the effect of once 1000 u coenzyme A（CoA） injection or capsule on postprandial triglyceride level after a high-fat meal in Chinese patients with fasting hypertriglyceridemia. Methods Ten healthy controls and 20 patients with fasting hypertriglyceridemia took a baseline high-fat meal（800 calories,50 g fat） after diet direction.And blood samples were collected at 0,2,4 and 6 h after the baseline meal.On the second day,all patients accepted a high-fat meal again and randomly took 1000 u CoA orally at 30 min before the meal or by intravenous drip immediately after the meal within 1 h.Blood samples were also collected at 0,2,4 and 6 h after the second meal.Blood lipids levels were assayed and percentages of increment in postprandial triglyceride level at 2,4 and 6 h after the meal were calculated. Results The postprandial serum triglyceride levels increased significantly at 2,4,6 h in patients while only at 2 h in healthy controls（P0.05）.Postp-randial serum total cholesterol,high density lipoprotein cholesterol and low density lipoprotein cholesterol levels did not change significantly when compared with their fasting levels,respectively.Taking all patients accepting CoA capsule or injection as a total（n=20）,a significant decrease was found in percentage of increment in postprandial triglyceride level at 6 h after CoA treatment（62.4%±13.1% vs 42.1%±9.2%,P0.05）.Subgroup analysis showed that both postprandial triglyceride level at 6 h（4.63±2.40 mmol/L vs 3.80±2.08 mmol/L,P0.05） and percentage of increment in postprandial triglyceride level at 6 h（62.8%±17.7% vs 39.0%±14.9%,P0.05） significantly decreased after CoA injection treatment.However,decreases of postprandial triglyceride level and percentage of increment in postprandial triglyceride level did not reach statistical significance in patients taking CoA capsule. Conclusion This small-s