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Multicomponent Domino [4＋1＋1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：TQ455.47[化学工程—农药化工] O621.3[理学—有机化学;理学—化学]
  • 作者机构：[1]School of Chemistry and Chemical Engineering, Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China
  • 相关基金：Acknowledgement We are grateful for financial support from the NSFC （Nos. 21072163, 21232004, 21272095, and 21102124）, PAPD of Jiangsu Higher Education Institutions, the NSF of Jiangsu Education Committee （11KJB150016）, and Jiangsu Science and Technology Support Program （No. BE2011045）, and the Qing Lan Project （12QLG006）.
作者： Ying Li Haiwei Xu Liping Fu Qingqing Shi Bo Jiang Shujiang Tu[1]
关键词： 酮衍生物, 区域选择性, 多米诺, 芴, 辐射条件, 三分量, 碳酸钾, 芳基, fluoren-9-one synthesis, multicomponent reactions, carbocyclization, regioselectivity, microwaveheating
中文摘要：

简明、有效的三部件的牙齿[4+1+1 ] 到 K2CO3 支持的高度代替的 fluoren-9-one 衍生物的 carbocyclization 在微波照耀条件下面被开发了。直接 bis-cyanation 和芳基胺化作用居住在 fluoren-9-one 框架在一个壶操作被完成。反应以快率和罐头继续在 30 min 以内被完成，它使 workup 方便给对优秀化学收益好。

英文摘要：

Concise and efficient three-component domino [4＋ 1 ＋ 1] carbocyclization to highly substituted fluoren-9-one derivatives promoted by K2CO3 has been developed under microwave irradiation conditions. The direct bis-cyanation and aryl amination residing in fluoren-9-one framework were achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good to excellent chemical yields.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175