中文摘要：

作者利用化学与生物活性相集成的筛选方法，从采自黄河三角洲地区——东营黄河口的梭鱼Chelon haematocheilus的内脏中分离鉴定了1株耐盐真菌土曲霉Aspergillus terreusOUCMDZ．1925，其发酵产物具有抗枯草芽孢杆菌活性。进一步采用色谱分离、波谱鉴定，从其固体发酵（大米培养基）中分离鉴定了5个化合物，即右旋丁内酯I（1）、丁内酯Ⅳ（2）、丁内酯Ⅱ（3）、丁内酯Ⅲ（4）和3,5，6-三甲基-2，4-二羟基苯甲酸甲酯（5）。并发现化合物1-3和5对金黄色葡萄球菌（ATCC51650）有强的抑菌活性（最小抑菌浓度均为0.31μg／mL，阳性对照环丙沙星的最小抑菌浓度为0．16μg／mL），化合物1和2对产气杆菌（ATCC13408）以及化合物1和3对枯草芽孢杆菌（ATCC93151）有中等的抑菌活性（最小抑菌浓度分别为6．25μg／mL和12．50μg／mL，阳性对照环丙沙星的最小抑菌浓度分别为1．25μg／mL和5．0μg／mL），化合物1-5对大肠杆菌（ATCC25922）以及化合物4对金黄色葡萄球菌（ATCC51650）有弱的抑制活性，且化合物1的产量高，达2．5g／kg，为其后续研究提供了新的药源。

英文摘要：

The Yellow River delta formed from the convergence of the Yellow River mouth and the Bohai Sea possesses a unique wetland environment different from both the sea and the land. This special ecosystem is rich in salt-and alkali-tolerant microorganisms. By means of an integrated chemical and antibacterial screening method, a salt-tolerant fungal strain,Aspergillus terreus OUCMDZ-1925 was isolated and identified from the internal organs of Chelon haematocheilus from the Yellow River estuary, Dongying, Shandong, China. The metabolites ofA. terreus OUCMDZ-1925 in solid state fermentation （rice medium） showed antibacterial effects on Bacillus subtilis. Chemical investigation resulted in the isolation and identification of （＋）-butyrolactone I （1） with high yield （2.5g/kg）, along with the other four minor polyketides, butyrolactone IV （2）, butyrolactone Ⅱ （3）, butyrolactone Ⅲ （4） and methyl 2,4-dihydroxy-3,5,6-trimethylbenzoate （5）. Compounds 1-3 and 5 showed strong antibacterial effects on Staphylococcus aureus （ATCC 51650） with MIC values of 0.31μg/mL （positive control, ciprofloxacin, MIC 0.16μg/mL）. The moderate antibacterial activities were first observed for compounds 1 and 2 against Enterobacter aerogenes （ATCC 13408）, and for compounds 1 and 3 against Bacillus subtilis （ATCC 93151） with MIC values of 6.25μg/mL and 12.50μg/mL, respectively （positive control, ciprofloxacin, MIC 1.25μg/mL and 5.0μg/mL, respectively）. In addition, compounds 1-5 and 4 displayed weak antibacterial effects on Escherichia coli （ATCC 25922） and S. aureus （ATCC 51650）, respectively.