中文摘要：

目的探讨抗幽门螺旋杆菌（Hp）治疗胃黏膜相关淋巴组织（MALT）淋巴瘤的远期效果及bcl-10在肿瘤对抗Hp治疗的反应性判断中的意义。方法选择12例Hp阳性胃MALT淋巴瘤，用免疫组化的方法检测肿瘤细胞bcl-10表达的情况，给予规范抗Hp治疗，并密切进行内窥镜随访。结果在单纯抗Hp治疗后6例获得完全缓解（CR），无一例检测到bcl-10核表达。余6例未达CR的病例中4例检测到bcl-10核表达。提示瘤细胞存在bcl-10的核表达，证明肿瘤的发展已与Hp作用无关，也提示临床，目前抗Hp治疗并非此类患者的首选治疗方案。这12例单纯抗Hp治疗CR率为50％（6／12），中位随访时间13．5个月。抗Hp后获得CR中位时间1．5个月，最长为6个月。至今，CR持续中位时间为14个月，最长达2年。结论抗Hp治疗可以使相当一部分胃MALT淋巴瘤患者获得CR，bcl-10核表达可能与肿瘤对抗Hp治疗不反应密切相关，但需进一步扩大样本量及延长随访时间证实。

英文摘要：

Objective To determine the long-term outcome of the gastric mucosa-associated lymphoid tissue lymphoma（MALT lymphoma） after helicobacter pylori（Hp） eradication and the significance of bcl-10 in the tumor＇s response to the Hp eradication. Methods 12 patients with Hp-positive gastric MALT lymphoma were enrolled in this study. We used immunochemistry stain to detect bcl-10 expression in the tumors and performed endoscopic follow-up after Hp eradication. Results bcl-10 nuclear expression was detected in 4 of 6 cases which did not acquire complete regression（CR） after Hp eradication and none was detected in 6 CR patients, indicating that the tumor progression might not be related to Hp infection and Hp eradication may be not the first choice and the only therapy method for bcl-10 nuclear expression patients. The total CR rate was 50 % （6/12） after Hp eradication with a median follow-up of 17.5 months. The median time achieved CR was 1.5 months with the longest one of 6 months. By now, the median duration of CR was 14 months with the longest one of 2 years, bcl-10 nuclear expression was not detected in the 6 CR cases, but in 4 of 6 who did not reach CR. Conclusion bcl-10 nuclear expression is more likely related to the non-response to the Hp eradication in the tumor. Hp eradication results in CR in part of gastric MALT lymphoma patients. However, it needs more cases and longer follow-up to confirm.