中文摘要：

DNAzymes (Dzs ) 是明确地劈开指向的基因的 mRNA 的搁浅单人赛的 DNA 催化剂。与另外的基因沉默技术相比，例如 ribozymes， antisense oligonucleotide 和小干扰 RNA (siRNA ) ， DNAzymes 有几个优点，包括的小分子的重量，差异，低费用和亲戚在浆液的稳定性。与分子的技术的进化，第一 DNAzyme 在 1994 在 vitro 被产生。从那时起， DNAzymes 被学习了以便理解他们的结构，化学和生物应用。特别地，当在许多的治疗的新干扰策略调节， DNAzymes 广泛地被使用了，包括癌症，病毒的疾病，和心血管的疾病。这评论主要在癌症研究和治疗的区域总结 DNAzymes 的使用。

英文摘要：

DNAzymes （Dzs） are single-stranded DNA catalysts that specifically cleave the mRNA of targeted genes. Compared with other gene-silencing technologies, such as ribozymes, antisense oligonucleotide and small interference RNA （siRNA）, DNAzymes have several advantages, including small molecular weight, diversity, low cost and relative stability in serum. With the evolution of molecular technology, the first DNAzyme was generated in vitro in 1994. From then on, DNAzymes have been studied in order to understand their structures, chemistry and biological applications. Particularly, DNAzymes have been widely applied as a new interference strategy in the treatment of many conditions, including cancer, viral diseases, and cardiovascular diseases. This re- view mainly summarizes the use of DNAzymes in the areas of cancer research and therapy.