中文摘要：

以对甲基苯胺为原料，设计合成了14个N-（6-甲基-3-氰基-4-芳胺基-7-喹啉）酰胺衍生物，其结构经EI—MS、^1H NMR、IR和元素分析确证。采用MTT法测试所合成化合物的体外抗肿瘤活性，结果表明，所合成的化合物均有一定的抗肿瘤作用，其中化合物13j对胃癌细胞AGS的体外抑制活性优于EKB-569和Bosutinib，抗肝癌细胞HepG2和结肠癌细胞HT-29的活性与阳性药相当。

英文摘要：

A series of N-（3-cyano-6-methyl-4-anilinoquinoline-7-yl） amide derivatives 13a-13n have been synthesized, their structures were confirmed with ^1H NMR, EI-MS, IR and elemental analysis. Antitumor activities of all the synthesized compounds in vitro were tested with MTT. Compound 13j showed better than or equal antitumor activity on Bosutinib and EKB-569.