类风湿关节炎(RA)在中医中属于“痹症”的范畴,多由“风、寒、湿”三邪阻滞经络,合而为病.许多疏风散寒、活血通络的中草药对于治疗RA有悠久的历史.随着现代医学的发展,传统中药及复方制剂治疗RA的疗效和机制越来越多地被揭示.针对该类研究进展的汇总,对于应用传统中医药治疗RA具有重要的指导意义,本文就目前主要传统中草药治疗RA的分子细胞学机制进行综述,希望能对临床应用传统中药治疗RA的策略提供借鉴.
In traditional Chinese medicine,rheumatoid arthritis (RA) belongs to the arthralgia syndrome, and is mainly caused by combination and blockage of meridian due to the 3 pathogenic factors,which are wind,cold as well as dampness.Many Chinese herbs with the effects of wind-dispersing and cold-dispelling and blood circulation promoting have well-established history of use in the treatment of RA.Along with the development of modem medicine, the effi- ciency and molecular mechanisms of Chinese herbs and compound remedy responsible for the treatment of RA have been more and more demonstrated.A summary of this area have an important guiding significance of the application of traditional Chinese medicine treatment of RA. Here we briefly review the studied molecular mechanisms of primary Chinese herbs in the treatment of RA and hope it could provide references for clinical treatment of RA.