中文摘要：

目的探讨湖南高血压人群血管紧张素转换酶基因和细胞色素P450 3A5基因多态性分布。方法高血压患者583名,其中403名娄底和湘潭地区原发性高血压病患者进行血管紧张素转换酶基因多态性检测;180名长沙和株洲地区原发性高血压患者进行细胞色素P450 3A5基因多态性检测。结果血管紧张素转换酶基因I和D等位基因频率分别为55.8%和44.2%,ID基因型最常见。细胞色素P450 3A5基因＊1和＊3等位基因频率分别为35.0%和65.0%,＊1＊3基因型最常见。在不同性别高血压人群中上述两种候选基因的基因型和等位基因频率差别均无统计学意义（P〉0.05）。结论湖南地区高血压人群血管紧张素转换酶基因和细胞色素P450 3A5基因多态性分布均符合Hardy-W e inberg遗传平衡,高血压人群中常见几类降压药物的主要代谢酶或受体的基因多态性存在个体差异,这为高血压人群单一药物治疗提供了初步的遗传学依据。

英文摘要：

Aim To approach polymorphism distribution of angiotensin converting enzyme（ACE） and cytochrome P450（CYP） 3A5 gene of hypertensive patients in Hunan province.Methods There were 583 hypertensive patients.ACE gene polymorphisms of 403 hypertensive patients in Loudi and Xiangtan were investigated.While,CYP3A5 gene polymorphisms of 180 hypertensive patients were investigated.Results ACE allele frequency was I（55.8%） and D（44.2%）,in order with ID as the highest genotype.CYP3A5 allele frequency was ＊1（35.0%） and ＊3（65.0%）,in order with ＊1＊3 as the highest genotype.No sex difference was found in genotypes and allele frequency distributions（all P0.05）.Conclusion Polymorphism distribution of ACE and CYP3A5 gene of hypertensive patients in Hunan province reached Hardy-Weinberg genetic balance,hypertension related drug metabolism enzyme and receptor gene polymorphisms showed the individual differences,which provided the previous genetical evidences for single-drug therapy in hypertension population.