中文摘要：

目的：测定磷酸川芎嗪的血浆蛋白结合率。方法：采用超滤法和高效液相色谱法对磷酸川芎嗪的血浆蛋白结合率进行测定。结果：磷酸川芎嗪与人血清白蛋白、人血浆和大鼠血浆的蛋白结合率分别为（64.64±0.68）%、（65.85±7.35）%及（73.65±2.35）%。结论：磷酸川芎嗪与血浆蛋白具有中等强度的结合。

英文摘要：

Objective：To study the plasma protein binding rate of Tetramethylpyrazine Phosphate.Methods：The ultrafiltration was employed to determine the plasma protein binding rate of Tetramethylpyrazine Phosphate.The plasma concentrations of Tetramethylpyrazine Phosphate were measured by RP-HPLC.Results：The plasma protein binding rate of Tetramethylpyrazine Phosphate with HSA、human plasma and rat plasma were（64.64±0.68）%、（65.85±7.35）% and（73.65±2.35）%,respectively.Conclusion： The binding rate of Tetramethylpyrazine Phosphate with plasma protein is middling strength.