中文摘要：

调查谷胱甘肽 S-transferase (GST ) 的角色的目的在吸烟的氧化应力和发炎的基因变体和标记 -- 相关冠的动脉疾病(CAD ) 病人。方法 535 个中国 CAD 病人是成功地 genotyped。血浆全部的抗氧化剂地位(道) ，谷胱甘肽， C 反应的蛋白质(CRP ) ，纤维蛋白原(小谎) 和白血房间计数(白血球) 决心评估氧化压力和煽动性的反应。结果 GSTM1-0/GSTT1-0 题目有更高的 CRP，小谎，白血球和 GSH 并且一与有野类型的 GSTM1/GSTT1 基因的病人相比的更低的道，但是关于道仅仅有重要差别。当时，有 GSTT1 的空遗传型的吸烟者有最高的 CRP 和最低的道和 GSH 与有与非吸烟的地位与非吸烟的地位，或 GSTT1-1 遗传型吸地位，或 GSTT1-0 遗传型的 GSTT1-1 遗传型相比。然而，我们没发现这些组之间的重要差别。另外，没有重要相互作用在决定 CRP 层次在遗传型和吸烟地位之间被观察。我们的结果建议多型性不修改的那 GST 的结论在中国 CAD 病人在氧化应力和发炎的标记上吸烟的效果。

英文摘要：

Objective： To investigate the role of glutathione S-transferase （GST） genetic variants and markers of oxidative stress and inflammation in smokingrelated coronary artery disease （CAD） patients. Methods： Five hundred and thirty-five Chinese CAD patients were successfully genotyped. Plasma total antioxidant status （TAOS）, glutathione, C-reactive protein （CRP）, fibrinogen（FIB） and white blood cell count （WBC） were determined to evaluate the oxidative stress and inflammatory response. Results： GSTM1-0/ GSTT1-0 subjects had a higher CRP, FIB, WBC and GSH and a lower TAOS compared to patients with wild-type GSTM1/GSTT1 genes, but there was significant difference only with regards to TAOS. Smokers with the null genotype of GSTT1 had the highest CRP and the lowest TAOS and GSH when compared to the GSTTI-1 genotype with smoking status, or the GSTT1-0 genotype with non-smoking status, or the GSTTI-I genotype with non-smoking status. However, we found no significant difference between these groups. Also, no significant interaction was observed between genotypes and smoking status in determining CRP levels. Conclusion： Our results suggest that GST polymorphisms do not modify the effect of smoking on markers of oxidative stress and inflammation in Chinese CAD patients.