斑马鱼由于具备便于获得、生长快速、实验费用小且与人类基因相似度较高等特点,近年来斑马鱼被广泛应用于人类疾病模型及药物筛选、毒理学与环境检测中,使其成为新型的脊椎模式生物。本文从模式动物在环境毒理学中的应用角度,论述了斑马鱼在环境毒理学研究中的实验方法和相关的检测指标,旨在为初涉斑马鱼研究工作的实验室和研究人员提供早期的工作借鉴,使斑马鱼的研究更好的应用于环境毒理学中。
Danio rerio,or Zebra fish,is an ideal modelling vertebrate which is experimentally accessible and costeffective. As is genetically similar to homo sapient,Zebra fish is comprehensively used in human disease modelling,drug screening,toxicology and environmental detection. This review demonstrates the application of zebra fish and its related indicators in ecotoxicological research,and hence provide a reference for further studies.