目的研究大接骨丹Torricellia angulata var.intermedia根皮的化学成分。方法采用硅胶、大孔树脂、Sephadex LH-20和ODS等色谱手段进行化学成分的分离纯化;依据理化性质、波谱数据和相关文献进行结构鉴定。结果分离鉴定了10个化合物,分别鉴定为丁香树脂酚(1)、豆甾醇(2)、3,4,5,7-四羟基-苯乙酸(3)、豆甾-5,11-二烯-3β-醇(4)、22,23-二氢豆甾醇(5)、β-胡萝卜苷(6)、26,27-dinor-4,4-dimethyl-cholesta-8,14-dien-3-ol(7)、硬脂酸(8)、软脂酸(9)、4-羟基-3,5-二甲氧基苯甲醛(10)。结论其中化合物3为新的天然产物,化合物1、2、4、5、7、10为首次从该植物中分离得到。
Objective To investigate the chemical constituents in the root bark of Torricellia angulata var.intermedia.Methods The compounds were isolated by means of column chromatography on silica gel,macroporous resin,Sephadex LH-20,and ODS,and their structures were elucidated by physicochemical properties and spectra.Results Ten compounds were obtained and identified as syringaresinol(1),stigmasterol(2),3,4,5,7-tetrahydroxy benzeneacetic acid(3),stigmasta-5,11-dien-3β-ol(4),22,23-dihydrostigmasterol(5),β-daucosterol(6),26,27-dinor-4,4-dimethyl-cholesta-8,14-dien-3-ol(7),octadecanoic acid(8),palmitic acid(9),and 4-hydroxy-3,5-dimethoxyl benzaldehyde(10).Conclusion Compound 3 is isolated from natural plant for the first time and compounds 1,2,4,5,7,and 10 are isolated from this plant for the first time.