中文摘要：

目前，临床使用的抗艾滋病药物主要是逆转录酶抑制剂和蛋白酶抑制剂。由于这些药物的毒性和耐药性等问题日益严重，寻找抗艾滋病药物的新靶点已经成为当务之急。在细胞水平上对HIV病毒自身生活周期的研究发现了一些新的药物靶点，其中包括病毒自身生活周期所需的蛋白，宿主细胞内源性抗病毒因子及其他抗HIV-1感染的潜在靶标。本文对近年来研究中出现的新的抗艾滋病药物靶点作一综述。

英文摘要：

Because of the emergence of viral resistance to protease and reverse transcriptase inhibitors, development of new drug targets for HIV therapy is urgently needed. Recent advances in our understanding of cellular pathways involved in the life cycle of HIV-1 have identified novel targets that may have potential for future antiretroviral intervention, including the viral proteins, the cellular proteins and other potential drug targets. In this review the development of new drug targets for anti-HIV therapy is summarized.