中药十八反、十九畏作为古代传统用药配伍禁忌由来已久,对相关理论的态度也是莫衷一是,没有一个统一的见解。该文从十八反、十九畏的产生源流到当代中医对其的不同认识,从毒理、药理、化学与信息等方面对十八反、十九畏的实验验证结果的分析归纳,来探讨十八反、十九畏的科学内涵。并提出中药十八反、十九畏每个组对各具特点,一个或几个组对不能作为整个十八反、十九畏的代表,必须系统研究其中的所有组对才能得出准确的结论。
The eighteen incompatible medicaments and nineteen medicaments of mutual restraint have been tought of traditional prohibited combination in long time, but people are unable to agree upon interrelated theories and can not reach an accordant consideration. From their origins and different comprehension of present TCM, this paper sum up and analyze previous experimental results in toxicology, pharmacology, chemistry and informatics so as to comprehend the scientific significance of the eighteen incompatible medicaments and nineteen medicaments of mutual restraint. We suggest that every drug pair has its own characteristic, one or several pairs can not typif the whole Eighteen Incompatible medicaments and nineteen medicaments of mutual restraint. Therefore the accurate modem understanding can only be reached until a systematic reseach on the whole drug pairs is done.