目的:对狼毒大戟的萜类成分进行研究。方法:采用硅胶柱层析色谱技术分离并纯化化合物,根据理化性质及波谱技术鉴定其结构。结果:从狼毒大戟的乙酸乙酯部位中分离得到8个二萜化合物和3个三萜化合物,分别鉴定为岩大戟内酯A(1),岩大戟内酯B(2),prostratin(3),ent-kaurane-3-oxo-16α,17-diol(4),antiquorin(5),neriifolene(6),ent-ati-sane-3β,16α,17-triol(7),kauranoic acid(8),乙酰木油树酸(9),24-亚甲基环木菠萝烷醇(10),乙酰羽扇豆醇(11)。结论:化合物4-10为首次从该植物中分得。
AIM:To study the terpenes in the roots of Euphorbia fischeriana.METHODS:The compounds were isolated by silica gel column chromatography,and their structures were identified on the basis of physiochemical and spectral data.RESULTS:Eight diterpenes and four triterpenes were obtained from the ethyl acetate extract,and their structures were elucidated as jolkinolide A(1),jolkinolide B(2),prostratin(3),ent-kaurane-3-oxo-16α,17-diol(4),antiquorin(5),neriifolene(6),ent-atisane-3β,16α,17-triol(7),kauranoic acid(8),aleuritolic acid(9),24-methyl-enecy- cloartanol(10)and lupenyl acetate(11).CONCLUSION:Compounds 4-10 were isolated from this plant for the first time.