中文摘要：

目的探讨孕期母鼠的炎症免疫刺激对子代大鼠老年期的血压及学习记忆的影响。方法24只孕鼠分别在孕期接受不同的处理，分为生理盐水对照组、内毒素（LPS）注射组、酵母多糖（Zym）注射组。子代大鼠出生后60周时，每组按随机数字表法选取8只，采用TNF-a ELISA试剂盒检测子鼠血清中炎症因子TNF-a的水平，用鼠尾动脉无创血压测定仪测量子鼠血压，通过Morris水迷宫实验检测其行为学变化，HE染色观察海马结构的病理改变。结果孕鼠在孕期接受炎症免疫刺激后所生的子代大鼠在60周时，血清中TNF-a的水平、动脉血压值均明显升高，学习记忆能力下降，海马CA1区局部神经元排列紊乱、数量减少。结论孕鼠孕期接受免疫炎症刺激可能是导致子代大鼠发生高血压和学习记忆能力降低的重要原因之一。

英文摘要：

Objective To explore the effect of prenatal inflammation on rat offspring＇ s blood pressure and behavioral performance. Methods Twenty-four time-mated Sprague-Dawley （SD） rats were randomly divided into three groups, i.e. control, zymosan and LPS. On their gestation days 8, 10, 12, the pregnant rats received i.p. injections of sterile saline, 0.79 mg/kg zymosan or 0.79 mg/kg LPS respectively. When the offspring were sixty weeks old, eight pups were chosen randomly for the later study. Their serum TNF-a level was detected by ELISA using tail blood, arterial blood pressure was measured by tail-cuff method, and their behav- ioral performance was detected in Morris water maze test. At the end of the experiment, the brains were rapidly taken from the sacrificed offspring, cut into sections and stained with H＆E method to investigate the structural changes of hippocampus. Results Compared with control showed increased serum level of TNF-a, increased systemic group, all offspring from the inflammation groups arterial blood pressure, long latency in finding the safe platform and decreased number of neurons in CA1 region of hippocampus. Conclusion Prenatal exposure to LPS or zymosan results in hypertension and disturbance of learning and memory.