目的:分析温肾类汤剂治疗PMOP的疗效和可能发生的不良反应。方法:电子检索9个国内外相关数据库,检索日期截止至2015年9月,并根据Cochrane Handbook5.1评价标准和工具评价纳入研究的质量,并用RevMan5.3软件进行Meta分析。结果:共纳入44项研究包括3878例患者,多数温肾类汤剂在提高患者血清雌二醇水平方面可能优于常规西药治疗,如疗程6个月时,温肾类汤剂对比常规西药提高患者血清雌二醇水平的WMD和95%cI为[3.2(0.43,5.97)];温肾类汤剂提高机体各部位骨密度水平可能优于温肾类中成药治疗,如疗程6个月时温肾类汤剂对比温肾类中成药提高患者腰椎骨密度WMD和95%CI为[1.38(0.13,1.63)];在调节患者血磷、血钙水平方面,因研究数较少或结论不一致尚未发现较明显的趋势。此外,温肾类汤剂治疗时未发现明显副作用。结论:依据现有临床研究资料分析温肾类汤剂治疗PMOP有临床意义,以温补肾阳为具体治法有一定疗效,汤剂较成药对部分症状的改善效果更佳。但因纳入研究质量以及临床疗效证据十分有限,需要更多设计严谨、实施严格、规模较大的临床研究加以证实。
Objective: To assess the benefits and harms of traditional Chinese medicine in the treatment of postmenopausal osteoporosis. Method: Electronic retrieval: Five English databases and four Chinese databases. Search deadline to September 2015. Postmenopausal women as the research object and we compared curative effect of randomized controlled trials of traditional Chinese medicine decoction with other traditional Chinese medicine. All trials were assessed according to the Cochrane Handbook 5.1 for Systematic Reviews of Intervention and analyses were performed by RevMan 5.3 Software. Results:A total of 44 studies were included in the study, including 3878 patients. Most of the Warming Kidney Decoction to improve the patients in serum estradiol levels and different parts of the bone density have certain curative effect and may be superior to Chinese patent drug and Western medicine treatment. For example, when the course of treatment is six months, Warming Kidney Decoction compared conventional western medicine to improve the serum level of estradiol in patients and Warming Kidney Decoction compared with traditional Chinese medicine to improve bone mineral density of the lumbar vertebrae in patients separately with the WMD 3.2 and 0.03, the 95% confidence interval 0.43 to 5.97 and O. 00 to 0.05. In the regulation of serum phosphorus and serum calcium levels, we have not yet found the obvious trend because of fewer or inconsistent conclusions. In addition, the treatment of Warming Kidney Decoction has not found significant side effects. Conclusion:On the basis of the existing clinical research data analysis, Warming Kidney Decoction can improve the sYmPtoms in the treatment of postmenopausal osteoporosis. However, because of the quality of the included studies and the clinical efficacy of the evidence is very limited. The reliability of conclusions needs to be more rigorous, serious and large-scale clinical study and provide evidence of a higher quality of clinical efficacy.