中文摘要：

G蛋白偶联受体（G protein-coupled receptor,GPCR）作为最大的一类人膜蛋白受体家族和最重要的药物靶标而倍受关注,其中钙离子在细胞内信号传导级联放大中起了关键的作用。阐述了GPCR和钙激活的氯离子通道蛋白（calcium-activated chloride channel,CaCC）中的钙信号网络与生理功能以及如何干扰阻断该网络,为药物设计和很多疾病的治疗提供了依据。

英文摘要：

G protein-coupled receptors （GPCR） are the largest class of human membrane protein receptors and drug targets which attract much attention, and calciumion plays a key role in intracellular signaling cascades amplification. This review focuses on calcium signal network of GPCR and calcium-activated chloride channel （CaCC） and how to interfere and block the network. It will provide a reference for the research of drug design and therapy of manydiseases.