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中文摘要：
游离胆固醇（FC）的沉积可以直接损伤肝细胞,通过破坏线粒体和内质网（ER）膜的完整性,触发线粒体氧化损伤以及ER应激,同时促进有毒的羟胆固醇产生,直接诱导脂肪组织功能紊乱.肝细胞胆固醇稳态失衡,包括胆固醇内流增加、外流减少以及肠肝循环障碍都参与了非酒精性脂肪性肝病（NAFLD）的发病机制.通过药物来纠正胆固醇稳态失调将开启治疗NAFLD的新篇章.
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