中文摘要：

皮肤是机体抵御外界环境中物理、化学伤害的第一道屏障,其依赖于表皮干细胞的增殖和分化而不断自我更新。整合素是一类细胞黏附受体,其调控细胞一细胞外基质反应,连接细胞外环境与细胞内信号通路,广泛参与增殖、分化和生存等细胞基本活动。本文就整合素分子在调控表皮干细胞的黏附、迁移、信号转导研究进展作一综述,从而为实现皮肤创伤的完美修复提供新的视角。

英文摘要：

Skin provides both a physical and a chemical barrier against the outside world, and keeps self-renewal through the proliferation and differentiation of epithermal stem cells. As one of the adhesion receptors, integrin mediates cell-ECM interactions and provides essential links between extracellular environment and intracellular signal pathways that play roles in many cell activities, such as proliferation, differentiation, and survival. In migration and signal transduction of epidermal stem cells, will wound healing. this article, the research progress of integrin in regulating adhesion, be reviewed to expand new insights for completing the perfect skin