中文摘要：

淀粉的肽(A) 聚集是在 Alzheimers 疾病(广告) 的致病的关键步。生产的抑制， A 的存在总数和清理的溶解对广告代表有效治疗学的策略。此处，新奇的铂(II ) 协调了 graphitic 碳氮化物(g-C ₃ N ₄) nanosheet (g-C ₃ N ₄@Pt) 被设计了 covalently 绑在 A 并且调制肽聚集和毒性。而且， g-C ₃ N ₄@Pt nanosheets 拥有高 photocatalytic 活动并且能氧化在可见轻照耀之上的 A，显著地 attenuating 聚集力量和 A 的 neurotoxicity。由于它穿过血大脑障碍(BBB ) 和它的好 biocompatibility 的能力， g-C ₃ N ₄@Pt nanosheet 是聚集的一个有希望的禁止者。这研究可以为为广告的处理使用的新奇多功能的 nanomaterials 的工程担任一个模型。

英文摘要：

Amyloid β-peptide （Aβ） aggregation is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of A[3 production, dissolution of existing aggregates and clearance of Aβ represent valid therapeutic strategies against AD. Herein, a novel platinum（II）-coordinated graphitic carbon nitride （g-C3N4） nanosheet （g-C3N4@Pt） has been designed to covalently bind to Aβ and modulate the peptide＇s aggregation and toxicity. Furthermore, g-CBN4@Pt nanosheets possess high photocatalytic activity and can oxygenate Aβ upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of Aβ Due to its ability to cross the blood-brain barrier （BBB） and its good biocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation. This study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of AD.