中文摘要：

低氧诱导因子-1α（hypoxia-inducible factor-1α,HIF-1α）是一种具有氧依赖性的核转录调控因子。在缺氧条件下HIF-1α大量聚集于细胞浆,继而转入细胞核促进靶基因转录表达,增强肿瘤的增殖、侵袭和转移能力;常氧条件下,HIF-1α的合成与降解水平保持相对平衡,其降解主要通过泛素-蛋白酶体途径实现。大量研究已经证实,去泛素化酶不仅可以有效逆转HIF-1α的泛素化-蛋白酶体降解过程,也可以通过各种途径促进肿瘤的发生发展,本文就去泛素化酶影响HIF-1α泛素化过程的作用机制作一综述。

英文摘要：

Hypoxia-inducible factor -la （HIF-la） is a kind of oxygen-dependent nuclear transcriptional factors. Under hypoxic conditions, HIF-la accumulates in cytoplasm and then transfers into nucleus to promote transcription and expression of its target genes enhancing proliferation invasion and metastasis of tumors; while under normoxic conditions, the synthesis and degradation of HIF-1 a protein remain relatively balanced. HIF-1 a is mainly degraded via the ubiquitin-proteasome pathway. Numerous studies showed that ubiquitination enzymes not only effectively reverses the ubiquitin-proteasome degradation process of HIF-la, but also promote the tumor progress through various ways. This review focus on the mechanisms of deubiquitination enzymes affecting ubiquitination of HIF- 1a.