目的:探讨利妥昔单抗联合 CHOP 方案(R-CHOP)治疗非霍奇金淋巴瘤合并非活动性 HBsAg 携带者的治疗方法。方法报道1例行 R-CHOP 方案治疗非霍奇金淋巴瘤合并非活动性 HBsAg 携带者患者,未行抗病毒治疗的疾病进程,并复习近年来国内外发表的相关文献。结果本例患者应用 R-CHOP 方案化疗前未行抗病毒治疗,引起HBV 再激活,致肝功能衰竭。结论应明确抗病毒治疗对防止非霍奇金淋巴瘤患者化疗过程中 HBV 再激活的重要性。
Objective To review the role of antiviral therapy among inactive HBsAg carriers with non-Hodgkin′s lymphoma (NHL)treated with rituximab in combination with CHOP chemotherapy (R-CHOP).Methods We reported an inactive HBsAg carrier with NHL who was treated with R-CHOP and developed liver failure,and the relevant literatures were reviewed.Results Lacking prnor-antiviral therapytreatment for hepatitis B virus infection before R-CHOP,which increased the risk of hepatitis flare-up in inactive HBsAg carriers with NHL,might cause damage to the liver and even eventually lead to full-blown liver failure.Conclusion Antiviral treatment for hepatitis B virus infection in inactive HBsAg carriers with NHL should be paid more attention.