中文摘要：

目的：比较四甲基偶氮唑盐（MTT）法与细胞病变效应（CPE）在筛选抗病毒药物中的异同。方法：在体外用两种方法检测阿昔洛韦（ACV）对细胞毒性作用和抗单纯疱疹病毒1型（HSV-1）的作用。结果：MTT法较CPE法敏感、客观、准确。结论：MTT法是一种快速、敏感、客观和准确的筛选和评价抗病毒药物的方法。

英文摘要：

Objective： To evaluate the difference between 5-diphenyl tetrazolium bromide（MTT）and cytopathic effect （CPE）in screening the antiviral medicine. Methods： Cytotoxity of acyclovlr（ACV）on Vero cell and antiviral activity of ACV on herpes simplex virus type 1（HSV-1） in vitro were detected using two methods. Results： MTT was more sensitive and objective than CPE. Conclusion： MTT is a rapid, sensitive, objective and accurate method for screening the antivival medicine.