中文摘要：

糖类不仅是组成生命体的基本物质之一，还是很多生理和病理过程中分子识别和细胞间相互作用的基础。糖的生物学功能可通过与蛋白质的相互作用来实现。这种可逆的特异性识别在信号传导、细胞粘附、增殖、分化、病菌感染和免疫应答等生命过程中具有重要意义。本文着重介绍了糖-蛋白质相互作用的种类和机理，综述了糖-蛋白质特异性识别作用在生物材料领域的应用进展，包括将糖类作为靶向分子修饰到纳米粒子或载体分子表面进行药物传递和基因转染，利用糖-蛋白质非共价作用力进行分子组装，以及制备糖基化表面用于调控蛋白粘附和细胞行为。由于糖类特殊的生物学性能和种类的多样性，基于糖-蛋白质特异性识别有望用于制备更加实用和智能的生物材料。

英文摘要：

The carbohydrates not only constitute the major components of life, but also are involved in a wide range of physiological and pathological processes, such as molecular recognition and cellular interactions. The biological functions of carbohydrate are achieved by specific interactions with proteins, playing an important role in signal transduction, cell adhesion, proliferation, differentiation, and inflammation and immunization. Besides the introduction of classification and mechanism for carbohydrate-protein interactions, this article briefly summarizes three main applications in biomedical field, including modification of nanoparticles with carbohydrate for drug delivery and gene transfection, formation of unique two- and three-dimensional supermolecular assemblies, and surface glycosylation to modulate protein adhesion and cell behaviors. More applications as intelligent biomaterials are expected to be explored in the future based on the carbohydrate- protein interactions.