组织一个链球菌(气体) ,重要人的病原体,能引起包括表面的感染的感染并且潜在地的各种各样的类型致命的感染,和搜索因为阻止煤气的感染的一支有效疫苗是进行中的许多年了。这份报纸把 FbaA (在气体的表面上表示的 Fn 有约束力的蛋白质) 的 immunogenicity 和 immunoprotection 与 M 蛋白质的作比较,气体的最好的 immunogen。为有免疫力的反应的试金显示出那 FbaA,类似于 M 蛋白质,能在 BALB/c 老鼠导致蛋白质特定的高 IgG titer。而且,跟随煤气的挑战,与 FbaA 使免疫的老鼠与 M 显示出象那些的一样的保护的率蛋白质。这些结果显示 FbaA 处于在在老鼠对煤气的挑战导致保护的免疫的 M 蛋白质的能力是类似的。
Group A streptococcus (GAS), an important human pathogen, can cause various kinds of infections including superficial infections and potentially lethal infections, and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA (an Fn-binding protein expressed on the surface of GAS) with that of M protein, the best immunogen of GAS. Assay for immune response showed that FbaA, similar to M protein, could induce protein-specific high IgG titer in BALB/c mice. Furthermore, following GAS challenge, the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. Cellular & Molecular Immunology.