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异氟醚后处理对缺血缺氧性脑损伤新生大鼠的长期脑保护作用及机制探讨
  • ISSN号:1002-266X
  • 期刊名称:山东医药
  • 时间:2014.7.11
  • 页码:1-4
  • 分类:R735.7[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:中国医科大学附属盛京医院麻醉科,沈阳110004
  • 相关基金:国家自然科学基金(81171782)
  • 相关项目:异氟醚后处理对新生大鼠缺血缺氧性脑损伤的保护作用及机制研究
中文摘要:

目的比较超声引导下腹横肌平面阻滞(transversus abdominis plane block, TAPB)与髂腹股沟及髂腹下神经阻滞(ilioinguinal/iliohypogastric nerve block, IINB)在小儿腹股沟区手术术中及术后早期的应用效果。方法选择择期进行单侧腹股沟区手术的患儿80例,年龄2-4岁,ASA分级I级。按随机数余数法分为TAPB组和IINB组,每组40例。两组患儿均于全身麻醉下行超声引导下TAPB或超声引导下IINB。分别观察与记录患儿的入室基础情绪,入室(T1)、切皮(T2)、缝皮(T3)时的HR、BP,手术时间、苏醒时间、PACU留观时间,改良加拿大东安大略儿童医院疼痛评分量表(modified children's hospital of eastern ontario pain scale, m-CHEOPS)评分、儿童麻醉后躁动评分(pediatric anesthesia emergence delirium, PAED)、PACU给药人数、术后恶心呕吐人数及患儿家长满意度。结果超声引导下TAPB组与IINB组在一般情况、基础情绪、局部麻醉药用量及入室的HR、BP方面差异无统计学意义(P〉0.05)。IINB组患儿在PACU首次、10、20、30min的m-CHEOPS评分都低于TAPB组,差异有统计学意义(P〈0.05),并且PACU给药人数IINB组也低于TAPB组[IINB组6人(15%),TAPB组15人(39%)],差异有统计学意义(P〈0.05);两组躁动发生率比较,差异没有统计学意义(P〉0.05),但IINB组的PAED评分明显低于TAPB组{IINB组PAED评分[中位数(四份位数间距)]3(0—14),TAPB组PAED评分6(0-16)),差异有统计学意义(P〈0.05);IINB组在术后恶心呕吐的发生率及家长满意度均低于TAPB组,但差异无统计学意义(P〉0.05)。结论超声引导下,相比于TAPB,IINB能为腹股沟区术后的小儿提供更为安全、高效的镇痛,是小儿腹股沟区手术术后镇痛的较佳选择。

英文摘要:

Objective To compare the efficacy of ultrasound guided transversus abdominis plane block (TAPB) and ilioinguinal/iliohypogastric nerve block (IINB) in providing postoperative analgesia after children groin surgery. Methods Eligible children, 2-4 years old (n=80), ASA I , undergoing elective unilateral groin surgery, were randomly assigned into IINB group (ultrasound guided ilioinguinal-iliohypogastric nerve block after routine general anesthesia) and TAPB group (ultrasound guided transversus abdominis plane block after routine general anesthesia). Funk sedation scores, intraoperative HR, BP at time points of before induction (T1), skin incision(T2) and skin closure(T3), length of surgery, the time from PACU arrival to the first obtainable pain score, length of PACU stay, modified children's hospital of eastern ontario pain scale (m-CHEOPS) pain scores, pediatric anesthesia emergence delirium (PAED) scores, number of children with sufentanil administered in PACU, number of people occurred nausea and vomiting, satisfaction of parents were measured and recorded during the study. Results There was no significant difference in general characteristics, basic emotion score, local anesthetic dose and the haemodynamic parameter between the IINB group and TAPB group (P〉O.05). However, the m-CHEOPS scores at the time points of first obtainable, 10, 20, 30 min in IINB group were lower than those in TAPB group (P〈0.05), and the number of children received sufentanil administration in IINB group were less than in TAPB group[IINB group: 6 children (15%), TAPB group: 15 children(39%)](P〈O.05). There was no statistical significant difference in the occurrence rate of delirium between the two groups (P〉O.05), whereas the PAED score of IINB group was lower than that in TAPB group[IINB group PAED score(median, inter-quartile range): 3(0-14), TAPB group PAED score: 6(0-16)] (P〈0.05). The occurrence rate of nausea and vomiting in IINB g

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期刊信息
  • 《山东医药》
  • 北大核心期刊(2014版)
  • 主管单位:山东省卫生和计划生育委员会
  • 主办单位:山东卫生报刊社
  • 主编:邱源
  • 地址:济南市燕东新路6号山东卫生报刊社
  • 邮编:250014
  • 邮箱:sdyy88516158@163.com
  • 电话:0531-88957404
  • 国际标准刊号:ISSN:1002-266X
  • 国内统一刊号:ISSN:37-1156/R
  • 邮发代号:24-8
  • 获奖情况:
  • 2009年第四届华东地区优秀期刊、2000年山东省自然...
  • 国内外数据库收录:
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  • 被引量:98858