中文摘要：

目的：检验越鞠丸有效缓解抑郁症的快速性。方法：抑郁症病人随机分为3组进行双盲对照研究。治疗组采用越鞠丸两种不同剂量合用氟西汀,对照组采用中药安慰剂加氟西汀,服用7 d后,停服中药。于服药前及服药后的第1,3,5,7,10天采用汉密尔顿抑郁量表（HAMD-24）及抑郁自评量表（SDS）进行疗效评定。结果：符合纳入标准病人中,越鞠实验组13例,越鞠普通剂量组10例,对照组9例。HAMD-24评分,越鞠实验组在第3,5,7天与对照组比显著降低,且停服中药3 d后差异仍然显著,而与服药前比,服药第3~第10天都有差异（P〈0.05）。服药后的第3天开始,HAMD迟滞因子有平行的显著改善（P〈0.05）。越鞠普通剂量组与对照组比较,及其分别与服药前比较均无显著差异。SDS评分结果与HAMD-24类似。结论：越鞠丸具有快速治疗抑郁症作用,主要是通过快速改善迟滞因子实现的。

英文摘要：

Objective： To test the rapid-onset of antidepressant effects of Yueju Pill. Methods： Patients were randomly assigned into three groups： experimental group（ treated with Yueju Pill at two different doses plus fluoxetine） and control group（ treated with placebo plus fluoxetine）. After combination treatment for 7 days,patients stopped taking the medicine. The efficacy was assessed by using the Hamilton Depression Rating Scale（ HDRS-24） and Self Rating Depression Scale（ SDS） at day 1,3,5,7and 10. Results： Thirty-two patients met the inclusion criteria（ 13 for experimental dose of Yueju Pill,10 for regular Yueju Pill dose and 9 for control group）. The HDRS-24 scores of patients taking the experimental dose of Yueju Pill were significantly decreased at day 3,5 and 7 when compared with the baseline level or the control group,and the remained effective after stopping Yueju Pill（ P〈 0. 05）. As for the subscale of retardation,the scores of patients taking the experimental dose of Yueju Pill were significantly decreased from day 3 to 10（ P 〈0. 05）. In contrast,during the testing period,there was no significant difference between patients taking the regular dose of Yueju Pill and placebo plus fluoxetine. Neither did they differ from their baseline levels,respectively. The results from SDS were similar to HDRS-24. Conclusion： Yueju Pill may have rapid-onset of antidepressant effects,likely via improvement in the retardation factor.